Everything about Demeclocycline totally explained
| PubChem = 5311063
| DrugBank = APRD00272
| C=21 | H=21 | Cl=1 | N=2 | O=8
| molecular_weight = 464.853 g/mol
| bioavailability =
| protein_bound = 41-50%
| metabolism = Hepatic
| elimination_half-life = 10-17 hours
| pregnancy_category = D
US
| legal_status =
| routes_of_administration = Oral 150 mg/300 mg
}}
Demeclocycline (marketed as
Declomycin,
Declostatin and
Ledermycin) is a member of the
tetracycline antibiotics group used in various types of
bacterial
infections. One of its other registered uses is the treatment of
hyponatremia (low blood
sodium concentration) due to the
syndrome of inappropriate antidiuretic hormone (SIADH) where fluid restriction alone has been ineffective. It is derived from the
Streptomyces aureofaciens fungal strain.
Mode of action
Its use as an antibiotic is particularly in
Lyme disease,
acne and
bronchitis. Resistance is gradually becoming more common. As with related tetracycline antibiotics, demeclocycline acts by binding to the
30S- and
50S-
RNA, which impairs
protein synthesis by bacteria. It is therefore
bacteriostatic (it impairs bacterial growth but doesn't kill bacteria directly). Demeclocycline is rarely used for infections.
The use in SIADH actually relies on a side-effect of tetracycline antibiotics; many may cause
diabetes insipidus (dehydration due to the inability to concentrate urine). It isn't completely understood why demeclocycline impairs the action of
antidiuretic hormone, but it's thought that it blocks the binding of the hormone to its
receptor.
Side-effects and interactions
These are similar to
other tetracyclines. Hypersensitivity may occur. Skin reactions with sunlight have been reported.
Contraindications
As
other tetracyclines, demeclocycline is contraindicated in children and pregnant or nursing women. All members of this class interfere with
bone development and may discolour
teeth. Tetracyclines bind with cations such as calcium and magnesium and becomes insoluble and inabsorbable for the GI tract. Tetracyclines shouldn't be given with milk or antacids.
Further Information
Get more info on 'Demeclocycline'.
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